Saturday, February 4, 2012

Possible Free Accounting Software for Your Business | Author ...

Due t? extreme competition ?n th? business world, ?t become very tough task t? r?n ?n? business successfully. It requires efficient ?nd intelligent business workers t? manage ?t well. Accounting software ??n exactly d? th?t f?r ???. It ??n provide ??? th? solution regarding t? management difficulties related t? accounts ?nd finance. Getting th? software b? downloading th?m free ?f cost ?? g??d thing. Free accounting software saves abundant amount ?f ???r wealth along w?th valued time. Saved wealth ??n b? fruitfully utilized ?n various ?th?r arenas ?f th? business. Y?? ?r? well known ?b??t accounting, financial ?nd ?b??t various payroll services associated w?th a business. Although th?? ?? n?t possible t? keep track ?f ?ll services until th? tracking procedure ?? extremely mechanized.

Free accounting software lessens number ?f errors wh??h ?r? bound t? occur wh?l? managing th? accounts manually.

Accounting software l?k? saas offers ??? w?th account payable module wh??h helps ??? t? pay th? bills easily, products ??r?h???? ?nd paying vendors ?n th? same time. Account receivable module allows analyzing various reports ?n th? ?th?r hand. It particularly helps th? company t? amend th??r policies ?nd marketing strategies, wh?n necessary. It ?l?? avails t? endow w?th general ledger wh??h ??n b? used t? keep a track ?f ?ll th? transactions ?nd divided ?nt? five categories wh??h ?r? known ?? assets, liabilities, equity, revenue ?nd expenses. It ?? ?l?? easy t? maintain pay periods ?nd wages ?f ?ll th? workers b? th? ??? ?f payroll application ?f th? ecommerce software. Free accounting software h??? a variety ?f traits ?? ?t ?? quite effortless t? bring ?nt? play, tough ?nd multiuser prop up wh?r? a lot ?f users ??n exploit th? software ?n tandem.

On th? ?th?r hand account receivable module allows ??? t? analyze various reports wh??h ??n tend t? formulate various useful future plans f?r th? business.

Th?? software particularly helps t? amend th? company along w?th required policies ?nd marketing strategies. It ?l?? offers th? facility ?f general ledger wh?r? one ??n keep track ?f ?ll th? transactions wh??h ?? divided ?nt? five uppermost categories usually known ?? assets, equity, expenses, revenues ?nd liabilities. Now ?t becomeseasier t? maintain pay periods ?nd wages ?f ?ll workers b? th? h?l? ?f payroll application ?f th? ecommerce software.Accounting software helps ??? t? m?k? ???r business fruitful ?nd ?t ?? quite easy t? ??? ?nd ??n b? used b? users ?t th? same time ??.

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Source: http://authoradvanced.com/possible-free-accounting-software-for-your-business.html

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Huge Blood stream Demands (Hypertension) - Health and Fitness ...

Meant for limiting an individual's hypertension, one can find several valuable tai-chi activities the fact that can help lessen any blood stream demands:

Inverted Tai-chi

Inverted tai-chi reverses any stage for gravity over the body system. Just about the most profound shifts brought about by Inverted Tai-chi set in stream. During inverted moves, limbs together with abdominal are placed on top of along with the.

Lengthening away from your limbs together with always keep him or her rather busy options . spinal cord breaks and also shape actively involved in the posture.

Among the many factors behind it's given that any induce for gravity is certainly reversed together with venous profit is very much bigger.

In most cases, any muscles groups within the calf together with other skeletal muscles groups during the lessen extremities will need to arrangement in an effort to pour unoxygenated blood stream together with waste products back in along with the from your veins.

During inverted moves, gravity results in any blood stream that will circulate conveniently to come back from your veins all this creates any blood stream demands during the your feet towards a least. The basically delivers skeletal muscles groups a way to slumber.

During Inverted moves, drainage for blood stream together with waste products within the lessen body system back in along with the is certainly amplified together with conditions which include varicose veins together with bloated ankles happen to be pleased.

Rhythmic Inhalation

It is actually a chance to understand more about inhalation, given that inhaling delivers the power to nourish your system together with serene your brain.

Not all ancient inhalation will conduct. For anybody who is like the majority of consumers, everyone require " light " breaths, push in your own gut at the time you inhale and exhale but not drain an individual's bronchi for carbon dioxide at the time you exhale.

I?ll tell you any physiological examination: Longer, impede breaths are definitely economical compared with simple, swiftly styles.
To take the best flow of air, an individual's bronchi will need to earliest get quite simply drain. Thereby the crucial element that will economical inhalation lies in exhaling thoroughly. A detailed exhalation starts out when using the high bust, receipts into the centre bust together with concludes utilizing tightening up any your mid-section.

Mainly searching for superior exhalation is it possible lure the best lungful within the oxygen-rich weather an individual's blood stream necessities meant for nourishing debris.

Source: http://health-advantage.blogspot.com/2012/02/huge-blood-stream-demands-hypertension.html

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Friday, February 3, 2012

Inboxhawk ? Different Types Of Vehicle Leasing Solutions

It is absolutely true fact hat these days vehicle leasing is becoming a very popular solution to lending to buying a business vehicle, but it can be a very beneficial solution for individuals as well. Every time you desire to buy a car or even simply rent some auto for a short period of time, vehicle leasing options could be the relevant answer.

It includes renting an automobile, similar to the facilities of leasing a house or an office. When opting for car lease, the finance company gets the automobile of your choice. They then give you a possibility you to use that automobile for the period of the lease in return for a payment that is to be covered per month.

If the automobile is used only for business needs, the repayments charged are completely tax deductible when automobile leasing. It included such issues as renting a depreciation which is your tax deduction.
Benefits
Some of the advantages of vehicle leasing are:
1. Rates can be a tax deduction for vehicles hired for business
2. Car leasing enables you to change your automobile every several years
3. Interest and monthly fees are fixed, so rates are known beforehand
4. Payments are generally considerably lower than a vehicle loan
5. The automobile is used as security against the car lease, so you may expect that the interest rates are normally much lower than automobile loans
6. They provide clients with pretty flexible terms from 2 to 5 years
7. You may get both brand new or used vehicles.

Types of car lease options available
1. operating vehicle leases,
2. finance vehicle leases
3. novated vehicle leases.
It is worth mentioning that the basic difference between finance and operating car lease facilities is at the end of the vehicle leasing term. In the case you opt for an operating lease, the lease lender retains ownership of the automobile leased, whereas in the event of finance leasing, the customer is required to pay out the balloon or residual fees and the client is to assume his ownership. Some issues at the end of a finance vehicle lease are as the following ones: pay out the balloon payment and have the car, trade in the automobile, or refinance the residual payment with some other automobile lease or loan.

It is necessary to admit that a fully maintained automobile lease is a finance leasing option that includes running rates of the car such as different services, tyres fuel, and so on and so forth. This type of automobile leasing is great if you need to have some fixed costs every month.

Novated vehicle leasing works rather differently to finance and operating solutions. In the event you are an employee wanting leasing a car, you are recommended to consider novated vehicle leasing if you desire to salary package an automobile.

Both comments and pings are currently closed.

Source: http://inboxhawk.com/2012/02/02/different-types-of-vehicle-leasing-solutions/

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VERDANT ZEAL MARKETING COMMUNICATIONS LTD ...

By admin on February 02nd, 2012

Verdant Zeal Marketing Communications Ltd is a leading multi-disciplinary marketing communications agency, providing innovative business solutions to an interesting mix of impressive clients, across diverse industries. As a result of business expansion, vacancies now exist for various job functions. Apart from a deep sense of passion & enthusiasm, prospective candidates MUST possess:

A Degree in relevant fields and not more than 35 years of age.
A minimum of 3 years work experience in the marketing communications industry and a provable sound track record.
APCON membership and/or relevant professional certifications.

1. ACCOUNT EXECUTIVES, BUSINESS SERVICE & BRAND DEVELOPMENT -REF NO: ACEO1VZ
2. ACCOUNT MANAGERS, BUSINESS SERVICE & BRAND DEVELOPMENT ? REF NO: ACM02VZ
As a key member of the client services team the Account Executive/Manager will:

Liaise closely with key Clients supporting top accounts by asserting expert insight into all things advertising and marketing.
Provide support to clients relating to advertising campaigns;
Establish close working relationships with internal teams to ensure smooth delivery on briefs.
Have close involvement in the creative and design process.
Manage account planning, business acquisition and strategic advertising activities;
Coordinate pitches?, alongside other agency soft, to win new businesses.
Have a lot of enthusiasm and passion that distinguishes him or herself as a practitioner

3. ACCOUNT DIRECTORS, BUSINESS SERVICE & BRAND DEVELOPMENT ? REF ACD03VZ
Person must possess a 2: 1 bachelor?s degree and at least 5 years industry experience in management capacity.
As the lead of the client services team, the Account Director will:

Be responsible for managing Account Managers and Executives.
Lead the team to create and develop opportunities to grow business with existing clients through excellent client, knowledge and relationships;
Lead, motivate and oversee the activities a sales focused account handling team

4. DEPUTY MANAGER, IDEAS ARCHITECTURE (COPYWRITING) -REF IAR04VZ
Person must possess a 2:1 Bachelors degree in English, Mass Communication or relevant fields.
The Idea Architect will:

work closely with the art director to architect and implement the overall look and feel of the outbound consumer communications materials.
Develop unique concepts and write all copy to support consumer communication efforts.
Writing Clear, persuasive and original copy that sells.
Proofreading copy to check spelling and grammar.
Amending, revising or redeveloping adverts or campaigns in response to feedback from the creative director. account management team or clients.
Overseeing campaigns through the production stage to completion.
Working on several campaigns at once, sometimes under pressure and often to tight deadlines.
Costing talents for TV and radio work, and listening to voice tapes to monitor campaigns.

5. ART DIRECTOR, CREATIVE -REF ARD05V2
Person must posses a 2: 1 Bachelor?s degree or HND in Graphic Art or relevant fields. Sample of jobs is required. He/She will:

Be responsible for production and communication of consistent stream of fresh ideas and visual concepts.
Deliver on high levels of IT skills in relevant art and design packages, embracing digital platforms.
Support the creative director in working with clients, stakeholders, account/project managers, strategy team members etc to develop concepts for presentation.

6. MANAGER, INNOVATION DEVELOPMENT & STRATEGIC INSIGHTS (EXPATRIATES WELCOME) -REF IDS06VZ
Person must possess a 2:1 Bachelor?s degree in Statistics, Mathematics or relevant disciplines with relevant professional certification. Sample of jobs is required. He/She will:

Design and plan market insight studies to meet the objectives of
(i) strengthening core brand values.
(ii) optimizing innovation opportunities and
(iii) developing new segment opportunities

Manage and carry out research duties including a blend of primary research (concept testing. message evaluation. target interviews) and secondary research (trend tracking, secondary report mining, sales presentation input and development, syndicated data reviews).
Provide a continuous, informative and insightful stream of relevant knowledge and insights about consumers, customers, competitors and marketplace dynamics complete with recommendations.
Champion and drive strategy sessions to provide winning ideas internally and as may be required externally by prospects and clients
Develop strong written and verbal communications, i.e. draft presentations and present them to both internal and client teams

7. BRANDED ENTERTAINMENT DIRECTOR/ CONSULTANT ? REF BED07VZ
Person must possess a 2:1 Bachelor?s degree in relevant fields. Sample of track record is required, He/She will:

Be responsible for creating, developing, managing and producing innovative branded content, communications and entertainment solutions and promotions for Verdant Zeal exploring several platforms.
Develop integrated marketing. Plans that identify key strategies, road maps. success metrics and resources to successfully complete projects.
Identify & cultivate new revenue opportunities with new and existing Clients.
Write and present client presentations including pitches, briefs and communications strategies.

8. MANAGER, SPECIAL PURPOSE REQUIREMENTS ? REF SPR08VZ
Person must possess a 2;1 Bachelor?s degree in relevant fields and project management certification. He/She will:

Coordinate all special purpose projects requirements, from start to finish, complete with reporting and payment, in a timely fashion: ensuring operations are carried out in conformity with terms and agreement thereto.
Manage all public sector related projects and accounts.
Build and actively manage relationships with all stoke holders in the public and private sectors on relevant projects.
Attend to all RFPs/RFls in a timely manner while ensuring on error-proof process.
Interface with all stakeholders of the business, to ensure proactive stakeholder management and effective response to operations related issues.
Oversee implementation of appropriate MIS and other corporate support function to drive streamlined decision making and effective business performance.
Prepare the SPY?s business plan and annual operating plan, including preparation and management of the Spy budget.

9. DEPUTY MANAGER, LEARNING & DEVELOPMENT ? REF LDE09VZ
Person must possess a 2:1 Bachelor?s degree in relevant fields with CIPMN certification. He/She will:

Have responsibility for end-to-end training activity for the core employees up to senior management level.
Work with business leaders and managers to identify training needs and trends within the business
Coordinate trainings such as inductions, commercial training, soft skills, management development and some technical skills.
Design training, both in-house and with expert third parties. a solution which includes a blended approach to learning such as coaching. classroom training. action learning and e-learning.
Prepare and Manage training budget.
Prepare, report and advise on training impact.

10. DEPUTY MANAGER, PORTFOLIO INVESTMENT ANALYST ? REF PIA10VZ
The Portfolio Investment Analyst must possess a 2: 1 Bachelor?s degree in Accounting, Economics or Finance with relevant professional qualification. MBA is on added advantage. He/She will:

Provide analytical support and investment strategies to Portfolio Managers.
Support the investment process through updating databases and maintaining records.
Assist in the analysis of relative valve and supporting generation and documentation of investment strategies based on relative value.
Conduct limited research projects providing weekly analytics tools.
Support tile analysis of overall performance through performance attribution and peer group analysis.

11. EXECUTIVE ASSISTANT TO THE GROUP MANAGING DIRECTOR ? REF EXA11VZ
The Executive Assistant to the Group MD must possess a 2: 1 Bachelor?s degree in a relevant discipline. Person must be on excellent communicator, articulate, polished, detailed and proficient in computer usage. He/She will:

Coordinate GMD?s travel & lodging bookings. documentation, filing (physical & electronic), events, etc.
Attend to GMO?s calls, correspondence and visitors.
Be responsible for Scheduling GMO?s meetings and appointments using relevant tools.
Track and follow up on GMO?s directives to staff and drive timely response to some.
Represent the GMD in meetings as may be delegated.

MODE OF APPLICATION
Send resume (in Word format) with a covering letter and within two weeks of this publication to: careers@verdantzeal.com
Please quote the job reference in the subject bar. Only shortlisted candidates would be contacted.
Remuneration is attractive, but emphasis is more on reword and retention.

DEADLINE: February 14, 2012.


Source: http://www.gosearchjobs.com/2012/02/verdant-zeal-marketing-communications-ltd-vacancies/

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Thursday, February 2, 2012

Video: Gingrich refuses to concede

Silva: Breaking down Super Bowl XLVI

Silva: Super Bowl XLVI isn't an exact rematch of Super Bowl XLII when the New York Giants shocked the New England Patriots. But that may be a good thing. What this one lacks in historical significance (no perfect season at stake) it makes up for in offensive firepower and sheer entertainment value, not to intriguing storylines on defense and special teams. So we broke it all down.

Source: http://www.msnbc.msn.com/id/3036697/vp/46227471#46227471

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Facebook's Risk Factors: Mobile, Gov, Slowed Growth, Google+ ...

Facebook?s?$5 billion?S-1 IPO filing includes a detailed assessment of business risks. These include: its lack of mobile monetization and the fact that it doesn?t own a mobile platform, government censorship and privacy scrutiny, inability to maintain its growth rate, and competition from Google+ as well as Twitter and Microsoft.

Here?s a closer look at these risks, followed by the full text of the risk summary, and you can see the whole Risk Factors section starting on page 10 of the S-1 filing to the SEC.

Growth and Engagement

Facebook explains its biggest challenge may be that:

?Our financial performance has been and will continue to be significantly determined by our success in adding, retaining, and engaging active users. We anticipate that our active user growth rate will decline over time as the size of our active user base increases, and as we achieve higher market penetration rates.?

As we?ve written about, Facebook has?saturated some of its key first-world markets in terms of user count.Some specific threats to its growth and engagement include competing products, failure to introduce well-received new products, inability to balance the user experience with the presence of ads, content relevancy, reduced perception of the service?s usefulness, and concerns about sharing, safety, and security.

Mobile

Facebook admits:

?We do not currently directly generate any meaningful revenue from the use of Facebook mobile products. Accordingly, if users continue to increasingly access Facebook mobile products as a substitute for access through personal computers?our revenue and financial results may be negatively affected?.

Simply put, Facebook?s mobile site and apps do not show ad sidebars, or ads of any kind. Many suspect Facebook will soon start serving Sponsored Story ads in the mobile news feed, but it will have to limit their presence to not offend users.

In regards to its lack of a mobile device or OS, Facebook states:

?We are dependent on the interoperability of Facebook with popular mobile operating systems that we do not control, such as Android and iOS, and any changes in such systems that degrade our products? functionality or give preferential treatment to competitive products could adversely affect Facebook usage on mobile devices.?

Google?s Android could give preference to Google+ and iOS already uses Twitter as its identity provider and native sharing option. Google and Apple could effectively box Facebook out of mobile if it doesn?t secure stronger relationships with them.

Additionally, Google and Apple control the native in-app payments systems on their mobile operating systems, preventing Facebook from earning its 30% tax on in-app purchases. Facebook has launched an HTML5 mobile app platform but it has failed to gain significant traction. Facebook may need to develop its own mobile OS or wait until HTML5 becomes more powerful, and by then it could be too late to catch up to Apple and Google?s mobile app platforms.

Competition

Facebook says competitors are attacking from all directions, stating:

?We face significant competition in almost every aspect of our business, including from companies such as Google, Microsoft, and Twitter, which offer a variety of Internet products, services, content, and online advertising offerings, as well as from mobile companies and smaller Internet companies that offer products and services that may compete with specific Facebook features. We also face competition from traditional and online media businesses for advertising budgets.?

This is one area where Facebook?s risk may not be as bad as it sounds. As I?ve detailed, the network effect of its interconnected user base protects it from disruption by similar services. Facebook has also been acquiring disruptive startups and talent. Through recent product launches like its asymmetrical Subcribe feature, Facebook has reduced Twitter?s threat.

Still, Google has enormous cash reserves and web presence to throw into the war with Facebook. Google knows identity as a layer that ties together activity on its various products is crucial to the future of its ad targeting business. Google+ may never have the world?s most popular news feed, but its ability to serve highly-targeted ads based on personal data and Google product usage could fracture social advertising demand.

Government Censorship and Privacy Regulation

Regarding the possibility of government censorship, Facebook notes:

?It is possible that governments of one or more countries may seek to censor content available on Facebook in their country, restrict access to Facebook from their country entirely, or impose other restrictions that may affect the accessibility of Facebook in their country for an extended period of time or indefinitely. For example, access to Facebook has been or is currently restricted in whole or in part in China, Iran, North Korea, and Syria.?

Facebook?s censorship in China is possibly the biggest barrier to its sustained growth. If it could gain entry there, it would quickly surge past 1 billion users. If more countries shut it out, it will have to squeeze a higher average revenue per user from its existing base. Facebook?s needs to build a crack team of international policy specialists and lobbyists to make sure there?s still a supply of fresh users to sign up.

Beyond censorship, Facebook is also subject to regulation:

?Our business is subject to complex and evolving U.S. and foreign laws and regulations regarding privacy, data protection, and other matters. Many of these laws and regulations are subject to change and uncertain interpretation, and could result in claims, changes to our business practices, increased cost of operations, or declines in user growth or engagement, or otherwise harm our business.?

Facebook recently?settled with US Federal Trade Commission?and survived an audit from the European Union?s?Office of the Irish Data Protection Commissioner. Through smart compromises and negotiations, it managed to avoid and dire consequences for its?business, but it might not be so lucky next time. Strong domestic and foreign lobbying presences will be necessary to avoid heavy scrutiny. Most importantly, Facebook needs to carefully consider any change or product launch that influences privacy to avoid stumbles like Beacon, the transition of interests into public Likes, and the opt out launch of facial recognition.

?

Additional risk factors include that Zynga makes up 12% of Facebook?s revenue, the company?s dedication to user engagement over short-term financial results, privacy and security leaks, patent lawsuits, and hacker attacks.

Full Text of the ?Summary Risk Factors?:

  • Our business is subject to numerous risks described in the section entitled ?Risk Factors? and elsewhere in this prospectus. You should carefully consider these risks before making an investment. Some of these risks include:
  • If we fail to retain existing users or add new users, or if our users decrease their level of engagement with Facebook, our revenue, financial results, and business may be significantly harmed;
  • We generate a substantial majority of our revenue from advertising. The loss of advertisers, or reduction in spending by advertisers with Facebook, could seriously harm our business;
  • Growth in use of Facebook through our mobile products, where we do not currently display ads, as a substitute for use on personal computers may negatively affect our revenue and financial results;
  • Facebook user growth and engagement on mobile devices depend upon effective operation with mobile operating systems, networks, and standards that we do not control;
  • We may not be successful in our efforts to grow and further monetize the Facebook Platform;
  • Our business is highly competitive, and competition presents an ongoing threat to the success of our business;
  • Improper access to or disclosure of our users? information could harm our reputation and adversely affect our business;
  • Our business is subject to complex and evolving U.S. and foreign laws and regulations regarding privacy, data protection, and other matters. Many of these laws and regulations are subject to change and uncertain interpretation, and could harm our business;
  • Our CEO has control over key decision making as a result of his control of a majority of our voting stock;
  • The loss of Mark Zuckerberg, Sheryl K. Sandberg, or other key personnel could harm our business;
  • We anticipate that we will expend substantial funds in connection with tax withholding and remittance obligations related to the initial settlement of our restricted stock units (RSUs) approximately six months following our initial public offering;
  • The market price of our Class A common stock may be volatile or may decline, and you may not be able to resell your shares at or above the initial public offering price; and
  • Substantial blocks of our total outstanding shares may be sold into the market as ?lock-up? periods end, as further described in ?Shares Eligible for Future Sale.? If there are substantial sales of shares of our common stock, the price of our Class A common stock could decline.

Source: http://techcrunch.com/2012/02/01/facebooks-risk-factors-mobile-gov-slowed-growth-google/

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Wednesday, February 1, 2012

Prostate cancer risk halved for subfertile men

Prostate cancer risk halved for subfertile men [ Back to EurekAlert! ] Public release date: 1-Feb-2012
[ | E-mail | Share Share ]

Contact: Yvonne Lundberg
Yvonne.Giwercman@med.lu.se
46-705-977-904
Lund University

Involuntary childlessness owing to reduced fertility is a concern for many men. However, these men do have one advantage they run a significantly lower risk of suffering from prostate cancer. Researchers are interested in whether this phenomenon could be used in the fight against cancer.

There is a clear link between male subfertility and a lower risk of prostate cancer. According to a new thesis from Lund University in Sweden, involuntarily childless men have around a 50 per cent lower risk of suffering from prostate cancer than men who have fathered at least one child.

Yasir Ruhayel, a doctoral student at Lund University and doctor at Skne University Hospital, has based his research on the Malm Diet and Cancer population study, where he has compared around 450 men with prostate cancer with an equal number of men in a control group who had not been diagnosed with the disease.

The thesis reinforces the findings of previous register-based studies, which have shown a connection, but this is the first time the issue has been studied in greater detail. An important conclusion is that the connection between reduced prostate cancer risk and subfertility is stronger than the connection between prostate cancer and other factors previously studied, for example diet, smoking, alcohol consumption and a number of different diseases.

Are there genetic explanations?

Yasir Ruhayel has also investigated whether variation in certain genes may be linked to the reduction in prostate cancer risk observed in the subfertile men.

"We have found certain genetic associations, but the results are preliminary and more extensive studies involving a larger number of men are needed before the significance of the genetics can be verified", says Yasir Ruhayel.

One of the identified candidate genes is the AHR gene, which interacts with the male and female sex hormone signalling systems. AHR is also known as the 'dioxin receptor' because it mediates the harmful effects of the environmental toxicant dioxin, which can affect fertility.

If future research is able to more accurately determine which genes reduce the risk of prostate cancer, then this may open up new opportunities to develop drugs. However, before this can happen the genes with the desirable properties must be considered in a broader context, because reduced fertility is usually caused by a number of factors. The cancer-blocking properties must also be separated out and isolated from the properties that reduce fertility.

The researchers at Lund University are also interested in the reverse situation whether it is possible to find ways of helping men with reduced fertility by studying the genes of men with prostate cancer.

###

Yasir Ruhayel defended his thesis, Male Subfertility and Prostate Cancer Risk: Epidemiological and Genetic Studies, on 27 January.

Link to thesis: http://www.lu.se/o.o.i.s?id=12588&postid=2269342

Contact:

For further information please contact supervisor and research group leader Yvonne Lundberg Giwercman: tel.: 46-70-597-79-04, Yvonne.Giwercman@med.lu.se

Yasir Ruhayel (available from 12 February): yasir.ruhayel@med.lu.se

Yasir Ruhayel is a doctoral student at the Department of Clinical Sciences in Malm, Faculty of Medicine, Lund University. He is also a medical doctor and a resident in urology at Skne University Hospital in Malm.

About prostate cancer

Prostate cancer is one of the most common types of cancer, affecting more than 10 per cent of Swedish men. Despite the high prevalence and frequently serious nature of the disease, there is still a lack of effective preventive treatment options and long-term cures. The most common diagnostic method is the PSA blood test, which is not generally considered to be a very reliable method. Many men undergo unnecessary operations with the risk of various adverse side-effects, in the view of the critics. Among those treated with 'androgen blockade' for more serious cases of prostate cancer, the cancer often returns within a few years and there is then no effective cure.

About childlessness and reduced fertility

Around one in seven couples have problems conceiving despite trying for at least a year. In roughly half of cases, the childlessness is due to the man's reduced fertility. Childlessness can be explained by both genetic and environmental factors.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Prostate cancer risk halved for subfertile men [ Back to EurekAlert! ] Public release date: 1-Feb-2012
[ | E-mail | Share Share ]

Contact: Yvonne Lundberg
Yvonne.Giwercman@med.lu.se
46-705-977-904
Lund University

Involuntary childlessness owing to reduced fertility is a concern for many men. However, these men do have one advantage they run a significantly lower risk of suffering from prostate cancer. Researchers are interested in whether this phenomenon could be used in the fight against cancer.

There is a clear link between male subfertility and a lower risk of prostate cancer. According to a new thesis from Lund University in Sweden, involuntarily childless men have around a 50 per cent lower risk of suffering from prostate cancer than men who have fathered at least one child.

Yasir Ruhayel, a doctoral student at Lund University and doctor at Skne University Hospital, has based his research on the Malm Diet and Cancer population study, where he has compared around 450 men with prostate cancer with an equal number of men in a control group who had not been diagnosed with the disease.

The thesis reinforces the findings of previous register-based studies, which have shown a connection, but this is the first time the issue has been studied in greater detail. An important conclusion is that the connection between reduced prostate cancer risk and subfertility is stronger than the connection between prostate cancer and other factors previously studied, for example diet, smoking, alcohol consumption and a number of different diseases.

Are there genetic explanations?

Yasir Ruhayel has also investigated whether variation in certain genes may be linked to the reduction in prostate cancer risk observed in the subfertile men.

"We have found certain genetic associations, but the results are preliminary and more extensive studies involving a larger number of men are needed before the significance of the genetics can be verified", says Yasir Ruhayel.

One of the identified candidate genes is the AHR gene, which interacts with the male and female sex hormone signalling systems. AHR is also known as the 'dioxin receptor' because it mediates the harmful effects of the environmental toxicant dioxin, which can affect fertility.

If future research is able to more accurately determine which genes reduce the risk of prostate cancer, then this may open up new opportunities to develop drugs. However, before this can happen the genes with the desirable properties must be considered in a broader context, because reduced fertility is usually caused by a number of factors. The cancer-blocking properties must also be separated out and isolated from the properties that reduce fertility.

The researchers at Lund University are also interested in the reverse situation whether it is possible to find ways of helping men with reduced fertility by studying the genes of men with prostate cancer.

###

Yasir Ruhayel defended his thesis, Male Subfertility and Prostate Cancer Risk: Epidemiological and Genetic Studies, on 27 January.

Link to thesis: http://www.lu.se/o.o.i.s?id=12588&postid=2269342

Contact:

For further information please contact supervisor and research group leader Yvonne Lundberg Giwercman: tel.: 46-70-597-79-04, Yvonne.Giwercman@med.lu.se

Yasir Ruhayel (available from 12 February): yasir.ruhayel@med.lu.se

Yasir Ruhayel is a doctoral student at the Department of Clinical Sciences in Malm, Faculty of Medicine, Lund University. He is also a medical doctor and a resident in urology at Skne University Hospital in Malm.

About prostate cancer

Prostate cancer is one of the most common types of cancer, affecting more than 10 per cent of Swedish men. Despite the high prevalence and frequently serious nature of the disease, there is still a lack of effective preventive treatment options and long-term cures. The most common diagnostic method is the PSA blood test, which is not generally considered to be a very reliable method. Many men undergo unnecessary operations with the risk of various adverse side-effects, in the view of the critics. Among those treated with 'androgen blockade' for more serious cases of prostate cancer, the cancer often returns within a few years and there is then no effective cure.

About childlessness and reduced fertility

Around one in seven couples have problems conceiving despite trying for at least a year. In roughly half of cases, the childlessness is due to the man's reduced fertility. Childlessness can be explained by both genetic and environmental factors.



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Source: http://www.eurekalert.org/pub_releases/2012-02/lu-pcr020112.php

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